There are two primary methods to produce water-for-injection (WFI) for cleanroom applications: multiple-effect distillation and vapor compression. Each method offers different advantages. Here are some key features to consider when determining the right WFI for you: The breaking point for ROI is 600 gallons/hour. The capital cost of vapor compression is higher than multiple-effect. However, […]

Relative humidity is a fickle issue in your cleanroom. Both outdoor and indoor factors affect it. Too much humidity will increase particulates and provide a breeding ground for biological contaminants. Too little humidity creates electrostatic discharge. Both instances can cause serious damage to your product and environment. The ideal humidity is right around 50 percent. […]

When it comes to your cleanroom, safety is multifaceted. Safety programs use OSHA standards, internal company requirements, and national consensus standards to ensure that work is performed ergonomically, efficiently, and safely. These programs are designed to protect employees and the integrity of the cleanroom. Your cleanroom safety plan should address appropriate employee behavior, functionality of […]

High purity solvents are a part of every critical process. They are just as important to critical products as the quality of air. While there is a generally accepted standard for high purity laboratory chemicals, specifications vary among chemicals. Solvent manufacturers offer additional grades, as well. So how do you know whether the solvent is […]

Your cleanroom is nothing without your air filtration system, and your filtration system is nothing without the right filter. The right filter, however, is not simply the one that fits and cleans the air to compliance. The right filter will spare you energy and headaches down the road. Here are a few things you should […]

Compliance in a cleanroom relies on proving you have good engineering practices (commissioning), and verifying facility/systems aspects that affect product quality (qualification). Carrying out these verifications can be quite overwhelming. John R. Butterfield describes each process in cemag.us’ “Commissioning and Qualification of Existing Facilities.” He also offers advice on how to prepare your facility for […]

Cleanroom garments are an integral part of any controlled environment. For some, hiring a laundering service is the most efficient way to get these garments clean. For others, having onsite laundry facilities is the best answer. If you decide to clean your own cleanroom garments, here is what you need to know. Cleanroom Washers & […]

There are several reasons one would establish a microbial monitoring program for a non-sterile cleanroom. Among them are evaluating sanitization and disinfection efficacy, monitoring cleanroom production and lab environments, monitoring and qualifying personnel, and validating the cleaning process in and of the cleanroom. One should always consult industry references for guidance, but we will outline […]